Our Publications
Microglia measured by TSPO PET are associated with Alzheimer's disease pathology and mediate key steps in a disease progression model
https://doi.org/10.1002/alz.13699
Samantha M Rossano, Aubrey Sperling Johnson, Anna Smith, Galen Ziaggi, Andrew Roetman, Diana Guzman, Amarachukwu Okafor, Julia Klein, Zeljko Tomljanovic, Yaakov Stern, Adam M Brickman, Seonjoo Lee, William C Kreisl, Patrick Lao
Alzheimer's & Dementia (2024)
Microglial Activation, but Not Tau Pathology, Is Independently Associated With Amyloid Positivity and Memory Impairment
DOI: 10.1016/j.neurobiolaging.2019.09.019
Zou, James, Sha Tao, Aubrey Sperling Johnson, Zeljko Tomljanovic, Krista Polly, Julia Klein, Qolamreza R. Razlighi et al.
Neurobiology of Aging 85 (2020): 11-21.
Untangling the Relationship Between Microglia and Tau in Alzheimer's Disease
DOI: 10.1016/j.tins.2021.10.002
Rossano, Samantha M., and William Charles Kreisl.
Trends in Neurosciences 44, no. 12 (2021): 927-929.
Olfactory Impairment Is Related to Tau Pathology and Neuroinflammation in Alzheimer's Disease
DOI: 10.3233/JAD-201149
Klein, Julia, Xinyu Yan, Aubrey Sperling Johnson, Zeljko Tomljanovic, James Zou, Krista Polly, Lawrence S. Honig et al. "Olfactory impairment is related to tau pathology and neuroinflammation in Alzheimer’s disease."
Journal of Alzheimer's Disease 80, no. 3 (2021): 1051-1065.
Deep Learning Improves Utility of Tau PET in the Study of Alzheimer's Disease
DOI: 10.1002/dad2.12264
Zou, James, David Park, Aubrey Sperling Johnson, Zeljko Tomljanovic, Davangere P. Devanand, Jose Luchsinger, Adam M. Brickman, William Charles Kreisl, and Frank Provenzano.
Alzheimer's & Dementia 17 (2021): e054310.
Patterns of Tau Pathology Identified With 18 F-MK-6240 PET Imaging
DOI: 10.1002/alz.12384
Kreisl, William Charles, Patrick J. Lao, Aubrey Sperling Johnson, Zeljko Tomljanovic, Julia Klein, Krista Polly, Benjamin Maas et al.
Alzheimer's & Dementia 18, no. 2 (2022): 272-282.
Posters & Abstracts
TSPO PET mediates tau-associated neurodegeneration in limbic and temporal regions across clinical variants of Alzheimer’s disease
Patrick Lao, Aubrey Johnson, Anna Smith, Diana Guzman, Hannah Houlihan, Amarachukwu Okafor, Lauren Heuer, ThairiSanchez, Andrea Maldonado, Catherine Palacios, Daniel Talmasov, Ndubisi Chikwem, Dina Dass, James Noble, William Kreisl, Scott Small
Multimorbidity and Alzheimer’s disease pathology across the lifespan in adults with Down syndrome
Anna Smith, Natalie Edwards, Lisi Aguilar-Flores, Mohamad Alshikho, Dana Tudorascu, H. Diana Rosas, Michael Yassa, Sigan L. Hartley, Benjamin Handen, Bradley Christian, Jose Gutierrez, Donna Wilcock, Elizabeth Head, Adam M. Brickman, Patrick Lao
Regional amyloid and tau: Exploring sex-based differences in a middle-aged community-based cohort
Diana S. Guzman, FrooghAziz, Anna C. Smith, Hannah Houlihan, ThairiC. Sanchez, Jose A. Luchsinger, Patrick J. Lao
Change in microglia density in relation to tau accumulation in older adults
Hannah Houlihan, Aubrey Johnson, Anna Smith, Diana Guzman, Amarachukwu Okafor, Lauren Heuer, Thairi Sanchez, DanielTalmasov, Ndubisi Chikwem, Dina Dass, James Noble, William Kreisl, Scott Small, Patrick Lao
MK-6240 Off-Target Binding Patterns in Relation to TSPO PET
Lauren B. Heuer, Aubrey S. Johnson, Anna Smith, Diana S. Guzmán, Hannah Houlihan, AmarachukwuOkafor, ThairiSanchez, Daniel Talmasov, Dina Dass, Nbdusi Chikwem, Frank Provenzano, William C. Kreisl, James Noble, Scott Small, Patrick J. Lao
Longitudinal changes in neuroimaging markers of small vessel disease in older adults with Down syndrome
Patrick Lao, Natalie Edwards, Lisi Aguilar-Flores, Batool Rizvi, Anna Smith, Dana Tudorascu, H. Diana Rosas, Michael Yassa, Benjamin Handen, Bradley Christian, Jose Gutierrez, Donna Wilcock, Elizabeth Head, Adam M. Brickman and the Alzheimer’s Biomarker Consortium-Down Syndrome
Differential association of alcohol use with neurodegeneration, cerebrovascular disease, and cognition in middle age
Diana S.Guzmán, Miguel Arce Rentería, Justina F.Avila, Indira C. Turney, Nadia J. Kress, Aubrey S. Johnson, Anna C. Smith, Amarachukwu Okafor, Hannah M. Houlihan, Lauren B. Heuer, Mohamad J. Alshikho, Clarissa Morales, Jessica Mazen, Yian Gu, Jennifer J. Manly, Adam M. Brickman, and Patrick J. Lao
The Impact of MeDi on AD Biomarkers in a Community Based Sample
Amarachukwu Okafor, Ambika Vartak, Aubrey Johnson, Diana Guzman, Anna Smith, Hannah Houlihan, Lauren Heuer, Miguel Arce-Renteria, Indira Turney, Richard Mayeux, Adam M. Brickman, Jennifer J. Manly, Yian Gu, Patrick Lao
Microglia density measured by TSPO PET across amyloid positivity and clinical variants
Hannah Houlihan, Aubrey Johnson, Anna Smith, Diana Guzman, Amarachukwu Okafor, Lauren Heuer, Daniel Talmasov, Ndubisi Chikwem, Dina Dass, James Noble, William Kreisl, Scott Small, Patrick Lao
Validating noninvasive techniques for [11C]ER176 PET quantification in controls and Alzheimer’s disease patients
Samantha M. Rossano, Daniel Talmasov, Aubrey S. Johnson, Anna C. Smith, Diana S. Guzmán, Amarachukwu Okafor,William C. Kreisl, Philip L. De Jager, Patrick J. Lao
Discovering Correlates of Off-Target 18F-MK6240 Signal in Community-Dwelling Adults
Aubrey S. Johnson, Amarachukwu Okafor, James Zou, Anna Smith, Diana S. Guzmán, William C. Kreisl, Adam M. Brickman, José A. Luchsinger, Patrick J. Lao
Elevated Tau burden in Amygdala and Hippocampus amongst older participants with psychosis
Aubrey S. Johnson, Galen Ziaggi, Hannah M. Houlihan, Anna C. Smith, Diana S. Guzmán, Amarachukwu Okafor, Edward D. Huey, William C. Kreisl, Daniel Talmasov, Patrick J. Lao
Tau burden is associated with sleep disordered breathing in adults with Down syndrome
Anna Smith, Sigan Hartley, David T. Plante, Aubrey S. Johnson, Diana S. Guzmán, Amarachukwu Okafor, Samantha Rossano, Dana Tudorascu, Adam M. Brickman, Bradley T. Christian, Ozioma Okonkwo, Beau Ances, Annie Cohen, Benjamin L. Handen, Patrick Lao
Moderate alcohol use, total brain volume, and white matter hyperintensities among racially and ethnically diverse middle-aged adults
Diana S. Guzmán, Miguel Arce Rentería, Justina F. Avila, Indira C. Turney, Samantha M. Rossano, Aubrey Sperling Johnson, Anna C. Smith, Amarachukwu Okafor, Clarissa Morales, Yian Gu, Jennifer J. Manly, Adam M. Brickman, Patrick J. Lao
Psychosis and tau burden in older adults
Aubrey S. Johnson*, Galen Ziaggi*, Anna Smith, Edward D. Huey,William C. Kreisl, Daniel Talmasov, Patrick Lao
*These authors contributed equally
Differential properties of Early vs. Late 18F-Florbetaben imaging acquisition time frames
Aubrey S. Johnson, Anna C. Smith, Zeljko Tomljanovic, Galen Ziaggi, Andrew E. Roetman, Julia Klein, Richard Keegan, Lawrence S Honig, William Charles Kreisl
Abstract: DOI:10.1002/alz.067766
