Sands Lab

The Sands Laboratory studies mouse and human cellular models in genes that cause severe childhood epilepsies, with the goals of understanding the molecular basis of disease and devising and testing novel therapies.

Research Overview

The Sands Laboratory is focused on understanding and treating epilepsy and neurodevelopmental disability caused by gene mutation (i.e., pathogenic variants in disease genes). Care of individuals affected by these conditions, including the group of severe early-onset epilepsies known as the developmental and epileptic encephalopathies (DEE), is currently restricted to treatments that target symptoms. Research in the Sands Laboratory is translational, focused on developing novel disease modifying therapeutic strategies. To accomplish this, we are using a combination of techniques from genetics and neuroscience in mouse and human cellular models. This work is driven by clinical experiences at bedside and is paralleled by a clinical research program focused on the electroclinical phenotypes of rare genetic epilepsies.
Epilepsy and Neurodevelopmental Disease Laboratory

Publications

For a complete list of publications, please visit PubMed.gov.