Peter Henry St George-Hyslop, OC, MD, FRCPC, FMedSci, FRS

  • Belle and Murray Nathan Professor of Neurology (in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain)
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Overview

Academic Appointments

  • Belle and Murray Nathan Professor of Neurology (in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain)

Gender

  • Male

Credentials & Experience

Education & Training

  • 1972 Faculty of Science, University of Ottawa, Ottawa, Ontario, Canada
  • MD, 1976 Faculty of Medicine, University of Ottawa,Ottawa, Ontario, Canada
  • Internship: 1977 St Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada
  • Residency: 1979 University of Ottawa, Ottawa Civic Hospital, Ottawa, Ontario, Canada
  • Residency: 1981 University of Toronto, St Michael’s Hospital, Toronto, Ontario, Canada
  • Residency: 1984 University of Toronto, Toronto, Ontario, Canada
  • Fellowship: Depts of Neurology and Genetics, Harvard Medical School, Neurogenetics Laboratory (J. Gusella), Massachusetts General Hospital, Boston, MA, USA

Honors & Awards

  • 2021 Margolese National Brain Disorders Prize (Canada)
  • 2018 Officer, Order of Canada (Canada)
  • 2017 Ryman Prize (New Zealand)
  • 2014 Dan David Prize, Tel Aviv (Israel)
  • 2012 BIAL Merit Award for Medical Research (Portugal)
  • 2009 Fellow of the Academy of Medical Sciences (UK)
  • 2007 Foreign Member, US National Academy of Medicine
  • 2007 Howard Hughes Medical Institute International Scholar Award
  • 2005 Matthew T. Moore Distinguished Lecturer, American Association of
  • Neuropathology
  • 2004 Fellow, Royal Society of London
  • 2002 Howard Hughes Medical Institute International Scholar Award
  • 2000 The F.E. Bennett Award, American Neurological Association
  • 1997 Howard Hughes Medical Institute International Scholar Award
  • 1996 The Potamkin Prize, American Academy of Neurology
  • 1993 The Gold Medal in Medicine, Royal College of Physicians of Canada

Research

Selected Publications

  1. Understanding physiological and pathological phase transitions of intrinsically disordered proteins
    1. Murakami T, Qamar S, Lin JQ, Kaminski Schierle GS, Rees E, Miyashita A, Costa AR, Dodd RB, Chan FTS, Michel CH, Kronenberg-Versteeg D, Li Y, Yang SP, Wakutani Y, Meadows W, Ferry RR, Dong L, Tartaglia GG, Giorgio Favrin7, Lin WL, Dickson DW, Zhen M, Ron D, Schmitt-Ulms G, Fraser PE, Shneider NA, Holt C, Vendruscolo M, Kaminski CF, St George-Hyslop PH. ALS/FTD mutation-induced phase transition of FUS liquid droplets and reversible hydrogels into irreversible hydrogels impairs RNP granule function. Neuron. 2015 Nov; 88(4):678-90. PMC4660210
    2. Qamar S, Wang G, Randle SJ, Ruggeri FS, Varela JA, Lin JQ, Phillips EC, Miyashita A, Williams D, Ströhl F, Meadows W, Ferry R, Dardov VJ, Tartaglia GG, Farrer LA, Kaminski Schierle GS, Kaminski CF, Holt CE, Fraser PE, Schmitt-Ulms G, Klenerman D, Knowles T, Vendruscolo M, St George-Hyslop P. FUS Phase is Modulated by a Molecular Chaperone and by Methylation of Arginine Cation-π Interactions. Cell. 2018, 173, 720–734. PMC5927716
    3. 3. Liao, YC., Fernandopulle, M., Wang G., Choi, H., Hao, L. Drerup, C.M., Qamar, S., Nixon-Abell, J., Shen, Y., Meadows, W., Vendruscolo, M., Knowles, T.P.J., Nelson, M., Czekalska, M., Musteikyte, G., Patel, R., Stephens, C., Pasolli, A., Forrest, L., St George-Hyslop, P., Lippincott-Schwartz, J., Ward, M.E.RNA granules hitchhike on lysosomes for long-distance transport, using annexin A11as a molecular tether. Cell, 2019 Sep 19;179(1):147-164 (2019). PMC6890474
  2. Development of novel tools for assessment of physiological and pathological phase transitions of intrinsically disordered proteins forming biomolecular condensates
    1. Shen Y, Ruggeri FS, Vigolo D, Kamada A, Qamar S, Levin A, Iserman C, Alberti S, St George-Hyslop PS, Knowles TPJ. Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition. Nature Nanotechnol. 2020 15(10):841-847: doi: 10.1038/s41565-020-0731-4. doi: 10.1038/s41565-020-0731-4. PMID: 32661370; PMCID: PMC7116851.
    2. Krainer G, Welsh TJ, Joseph JA, Espinosa JR, Wittmann S, de Csilléry E, Sridhar A, Toprakcioglu Z, Gudiškyt? G, Czekalska MA, Arter WE, Guillén-Boixet J, Franzmann TM, Qamar S, St George-Hyslop P, Hyman AA, Collepardo-Guevara R, Alberti S, Knowles TPJ. Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions. Nat Commun. 2021 12(1):1085. PMID: 33597515; PMCID: PMC7889641.
    3. Arter WE, Qi R, Krainer G, Welsh TJ, Xu Y, St George-Hyslop PH, Alberti S, Knowles TPJ. Rapid Generation of Protein Condensate Phase Diagrams Using Combinatorial Droplet Microfluidics bioRxiv 2020.06.04.132308; /doi.org/10.1101/2020.06.04.132308
    4. Shen Y, Ruggeri FS, Vigolo D, Kamada A, Qamar S, Levin A, Iserman C, Alberti S, St George-Hyslop PS, Knowles TPJ. Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition. Nature Nanotechnol. 2020 15(10):841-847: doi: 10.1038/s41565-020-0731-4. PMC7116851
  3. Genetic association and functional genetics of AD genes involved in endocytosis and endosome biology SORL1, ABCA7
    1. Rogaeva E, Meng Y, Lee JH, Gu YJ, Kawarai K, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, lnzelberg R, Hampe W, Bujo H, Song Y, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux RP, Farrer LA, St George-Hyslop The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer's Disease. Nature Genetics. 2007, 39:168-177. PMC2657343
    2. Vardarajan BN, Zhang Y, Lee JH, Cheng R, Bohm C, Ghani M, Reitz C, Reyes-Dumeyer D, Shen Y, Rogaeva E, St George-Hyslop P, Mayeux R. Coding mutations in SORL1 and Alzheimer disease. Ann Neurol. 2015; 77(2):215-27. PMC4367199
    3. Satoh K, Abe-Dohmae S, Yokoyama S, St George-Hyslop P, Fraser PE. ABCA7 Loss of Function Alters Alzheimer Amyloid Processing. J Biol Chem. 2015, 290(40):24152-24165. PMC4591804
    4. Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, NortonJ, Budde J, Bertelsen S, Jeng AT, Cooper B, Skorupa T, Carrell D, Levitch D, Hsu S, Choi J, Ryten M; UK Brain Expression Consortium, Hardy J, Ryten M, Trabzuni D,Weale ME, Ramasamy A, Smith C, Sassi C, Bras J, Gibbs JR, Hernandez DG, LuptonMK, Powell J, Forabosco P, Ridge PG, Corcoran CD, Tschanz JT, Norton MC, MungerRG, Schmutz C, Leary M, Demirci FY, Bamne MN, Wang X, Lopez OL, Ganguli M, Medway C, Turton J, Lord J, Braae A, Barber I, Brown K; Alzheimer’s Research UKConsortium, Passmore P, Craig D, Johnston J, McGuinness B, Todd S, Heun R, KölschH, Kehoe PG, Hooper NM, Vardy ER, Mann DM, Pickering-Brown S, Brown K, Kalsheker N, Lowe J, Morgan K, David Smith A, Wilcock G, Warden D, Holmes C, Pastor P, Lorenzo-Betancor O, Brkanac Z, Scott E, Topol E, Morgan K, Rogaeva E, Singleton AB, Hardy J, Kamboh MI, St George-Hyslop P, Cairns N, Morris JC, Kau, JS, Goate AM. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature. 505(7484):550-4. doi:10.1038/nature12825 PMID: 24336208 (2014). PMC4050701
  4. Genetic and functional studies on TREM2, CD33, PLCG2 and ABI3 microglial genes
    1. Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A, Hardy J; Alzheimer Genetic Analysis Group. TREM2 variants in Alzheimer's disease. N Engl J Med. 2013; 368(2):117-27. PMC3631573
    2. Sims R, van der Lee SJ, Naj A, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle J, Boland A, Raybould R.. St George-Hyslop P.. GERAD/PERADES, CHARGE, ADGC, EADI.. Lambert JC, Seshadri S, Williams J, Schellenberg GD. Novel rare coding variants in PLCG2, ABI3 and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease. Nature Genetics 2017 49(9):1373-1384. PMC5669039
    3. Joshi P, Riffel F, Satoh K, Enomoto M, Qamar S, Scheiblich H, Villacampa N, Kumar S, Theil S, Parhizkar S, Haass C, Heneka MT, Fraser PE, St George-Hyslop P, Walter J. Differential interaction with TREM2 modulates microglial uptake of modified Aβ species. Glia. 2021 69(12):2917-2932. PMID: 34427354.
    4. Vilalta A, Zhou Y, Sevalle J, Griffin JK, Satoh K, Allendorf DH, De S, Puigdellívol M, Bruzas A, Burguillos MA, Dodd RB, Chen F, Zhang Y, Flagmeier P, Needham LM, Enomoto M, Qamar S, Henderson J, Walter J, Fraser PE, Klenerman D, Lee SF, St George-Hyslop P, Brown GC. Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation. J Biol Chem. 2021 296:100631. doi: 10.1016/j.jbc.2021.100631. PMID: 33823153; PMCID: PMC8113883.
  5. Cloning, Functional genomics and Structural Biology of the presenilin genes
    1. Sherrington R, Rogaev E, Liang Y, Rogaeva E, Levesque G, Ikeda MH, Chi H, Lin C, Li G, Holman K, Tsuda T, MarL, Foncin J-F, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee Y, Chumakov D, Pollen D, Tanzi RE, Wasco W, Haines JL, DaSilva R, Pericak-Vance MA, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH. Cloning of a novel gene bearing missense mutations in early onset familial Alzheimer Disease. Nature. 1995; 375: 754-760.
    2. Citron M, Westaway D, Xia W, Carlson G, Diehl TS, Seubert P, Kholodenko D, Motter R, Schenk D, Kim S, Levesque G, Sherrington R, St George-Hyslop P, and Selkoe DJ. Mutant presenilins of Alzheimer's Disease increase production of 42 residue amyloid B-protein in both transfected cells and transgenic mice. Nature Med. 1997; 3: 67-72.
    3. Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song Y-Q, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang D-S, Holmes E, Milman P, Liang Y, Zhang D-M, Xu D-H, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer L, Sorbi S, Bruni AC, Fraser PE, St George-Hyslop PH. Nicastrin modulates presenilin-mediated Notch/Gip1 signal transduction and bAPP processing. Nature. 2000; 407:48-54.
    4. Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, lwatsubo T, Johnson CM, Farrer LA, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH. Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure. 2014; 22(1):125-135. PMC3887256

For a complete list of publications, please visit PubMed.gov