Overview
Academic Appointments
- Professor of Neuropsychology (in Neurology and in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H. Sergievsky Center)
Gender
- Male
Credentials & Experience
Education & Training
- PhD, Psychology and Neuropsychology, Graduate School of the City University of New York
- Neuroscience and Psychology, Oberlin College
- Internship: Brown Medical School
- Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center
Committees, Societies, Councils
- 2014: Fellow of the American Psychological Association (APA)
Research
Dr. Brickman uses advanced neuroimaging techniques to understand cognitive aging and dementia. He is particularly interested in white matter abnormalities and the intersection between vascular disease and Alzheimer's disease.
Ongoing Research: The effect of age on neuromorphology and its cognitive consequences. His current research efforts focus primarily on "normal" cognitive and structural changes across the adult lifespan. Specifically, he uses structural magnetic resonance imaging (MRI) to try to identify specific areas in the brain or coordinated patterns of brain tissue that are most vulnerable to the effects of age. Although age-associated decline across several neurocognitive domains has been well-documented, how age-associated differences in the brain's structure impacts cognitive abilities is still poorly understood. He is addressing this issue with a focus on individual differences in cognitive aging and on potential moderators and mediators of the relationships among age, neuromorphology, and cognition. He is particularly interested in understanding how cognitive reserve and cerebrovascular risk factors interact with the aging brain and cognitive abilities. For MRI quantification, these studies use traditional manual-tracing region-of-interest (ROI) approaches, ROI templates, white matter hyperintensity quantification protocols, voxel based morphometry, and novel multivariate/covariance analytic techniques. He also has an interest in using structural and functional neuroimaging techniques, traditional neuropsychological approaches, and functional assessment to understand neuro/psychiatric disorders, such as schizophrenia and dementia.
Research Interests
- Aging
- Alzheimer's Disease
- Cognitive Aging
- Dementia
- Down Syndrome
- Functional and Structural Neuroimaging
- Magnetic Resonance Imaging (MRI)
- Neuroimaging
- Neurology
- Neuromorphology
- Neuropsychiatric Disorders
- Neuropsychology
- Schizophrenia
Selected Publications
- Liou JJ, Lou J, Flores-Aguilar L, Nakagiri J, Yong W, Hom CL, Doran EW, Totoiu MO, Lott I, Mapstone M, Keator DB, Brickman AM, Wright ST, Nelson B, Lai F, Xicota L, Dang LT, Li J, Santini T, Mettenburg JM, Ikonomovic MD, Kofler J, Ibrahim T, Head E; Alzheimer Biomarker Consortium ? Down Syndrome. A neuropathology case report of a woman with Down syndrome who remained cognitively stable: Implications for resilience to neuropathology. Alzheimers Dement. 2025 Feb;21(2):e14479. doi: 10.1002/alz.14479. Epub 2025 Jan 27. PMID: 39868632; PMCID: PMC11851131.
- Kennedy JT, Wisch JK, Dincer A, Roman J, Gordon BA, Handen B, Benzinger TLS, Head E, Mapstone M, Christian BT, Tudorascu DL, Laymon CL, Hartley SL, Lao P, Brickman AM, Zaman SH, Ances BM; ABC?DS and DIAN Consortia. Decoding brain structure to stage Alzheimer's disease pathology in Down syndrome. Alzheimers Dement. 2025 Feb;21(2):e14519. doi: 10.1002/alz.14519. Epub 2025 Jan 14. PMID: 39807622; PMCID: PMC11848172.
- Lee JH, Scambray KA, Morris EP, Sol K, Palms JD, Zaheed AB, Martinez MN, Schupf N, Manly JJ, Brickman AM, Zahodne LB. Marital status, brain health, and cognitive reserve among diverse older adults. J Int Neuropsychol Soc. 2024 Nov 26:1-10. doi: 10.1017/S1355617724000638. Epub ahead of print. PMID: 39587737.
- Rosas HD, Mercaldo ND, Hasimoglu Y, Petersen M, Lewis LR, Lai F, Powell D, Dhungana A, Demir A, Keater D, Yassa M, Brickman AM, O'Bryant S. Association of plasma neurofilament light chain with microstructural white matter changes in Down syndrome. Alzheimers Dement (Amst). 2024 Nov 22;16(4):e70023. doi: 10.1002/dad2.70023. PMID: 39583646; PMCID: PMC11582681.
- Lee AJ, Sanchez D, Reyes-Dumeyer D, Brickman AM, Lantigua RA, Vardarajan BN, Mayeux R. Reliability and Validity of Self-Reported Vascular Risk Factors: Hypertension, Diabetes, and Heart Disease, in a Multi-Ethnic Community Based Study of Aging and Dementia. J Alzheimers Dis. 2023;95(1):275-285. doi: 10.3233/JAD-230374. PMID: 37483004; PMCID: PMC10578288.
- Calcetas AT, Thomas KR, Edmonds EC, Holmqvist SL, Edwards L, Bordyug M, Delano-Wood L, Brickman AM, Bondi MW, Bangen KJ, For The Alzheimer's Disease Neuroimaging Initiative. Increased regional white matter hyperintensity volume in objectively-defined subtle cognitive decline and mild cognitive impairment. Neurobiol Aging. 2022 Oct;118:1-8. doi: 10.1016/j.neurobiolaging.2022.06.002. Epub 2022 Jun 16. PMID: 35809348; PMCID: PMC9838569.
For a complete list of publications, please visit PubMed.gov